Pharmacokinetics (PK) relates to how the concentration of a drug (often measured in plasma) changes with time after dosing.  Essentially pharmacokinetics drives exposure, efficacy, dosing regimens and drug-drug interactions.

 

Early animal PK is used to help assess predicted dose into humans and subsequent suitable human pharmacokinetics. 

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+Understanding the pharmacokinetics of your compound is essential

+PK does not sit in isolation and is relevant to both preclinical and clinical development

+Understand clearance and volume of distribution to allow clinical prediction

+Supports choice of toxicology species

+Enhances link between exposure and safety

+Understand correlation between pharmacokinetics, pharmacodynamics and toxicokinetics

+ Allows prediction of potential drug-drug interactions

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